Omega-6 fatty acids increase fat accumulation in type 2 diabetes

Recently, a study in the Journal of Internal Medicine showed that 0mega-6 fatty acids may cause fat accumulation and insulin resistance in patients with type 2 diabetes. specific, the researchers found that high serum eicosatrienoic acid (DGLA) is associated with fat accumulation and Insulin resistance in patients with type 2 diabetes in Japan, especially obesity.
The aim of this study was to elucidate the association between 0mega-6 and omega-3 polyunsaturated fatty acid levels in serum of diabetic subjects and other obesity-related metabolic parameters.

Existing studies have shown that Omega-3 and 0mega-6 polyunsaturated fatty acids have "opposite effects" on adipogenic or adipose tissue browning and brain-intestinal adipose tissue axis and systemic inflammation. Elevated levels of Omega-6 fatty acids are also associated with weight Gain and also increase the incidence of type 2 diabetes.
The researchers calculated the subject's body mass index (BMI) and waist circumference.During the 12-hour fasting period, the researchers collected blood samples.To assess participants' serum polyunsaturated fatty acids, the researchers used a gas chromatography-flame ionization assay. They used data to measure the immunoreactive insulin levels in subjects by enzyme-linked immunoreactivity.
The results of the analysis showed that the higher the serum DGLA level, the higher the obesity, body fat accumulation, and the higher the alanine aminotransferase level, the stronger the insulin resistance.The researchers point out that excessive intake of 0mega-6 polyunsaturated fatty acids is associated with obesity and its associated metabolic abnormalities. There was no consistent correlation between serum 0mega-3 fatty acid levels and obesity-related parameters.
By further studying these connections, health practitioners may in turn be able to more effectively assessing metabolic abnormalities and eating habits in diabetic patients. Measurement of serum PUFA levels may be helpful in assessing obesity-related metabolic abnormalities and assessing a patient's eating habits.
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